Stewart L. MacLeod, PhD |
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| Research Assistant Professor, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences |
| Phone: (501) 364-4616 |
Research Overview
Dr. MacLeod is the technical director of the Genomics laboratory in the Center for Birth Defects Research and Prevention at the Arkansas Children’s Hospital Research Institute. The focus of the research conducted by the lab is to determine the underlying genetic factors that contribute to the risk of structural birth defects, with special interest in genetic polymorphisms in genes involved in folate metabolism. In addition, we have also undertaken an investigation into the role of differential DNA methylation as a contributor to birth defects risk.
Key Publications*
MacLeod SL, Sinha R, Kadlubar FF, Lang NP. Polymorphisms of CYP1A1 and GSTM1 influence the in vivo function of CYP1A2. Mutation Research. 376:135-142, 1997.
MacLeod, S. L., Nowell, S., Plaxco, J., Lang, N.P. An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer, Annals of Surgical Oncology. 7: 777-782, 2000.
MacLeod SL. Nowell S. Massengill J. Jazieh A. McClure G. Plaxco J. Kadlubar FF. Lang NP. Cancer therapy and polymorphisms of cytochromes P450. Clinical Chemistry & Laboratory Medicine. 38(9): 883-887, 2000.
Pashov A. Canziani G. Macleod S. Plaxco J. Monzavi-Karbassi B. Kieber-Emmons T. Targeting carbohydrate antigens in HIV vaccine development. Vaccine. 23(17-18):2168-75, 2005.
Ross CC. MacLeod SL. Plaxco JR. Froude JW. Fink LM. Wang J. Stites WE. Hauer-Jensen M. Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium. Radiation Research. 169(4):408-16, 2008 Apr.
*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.
Research Support
Co-Investigator: Genetic and Metabolic Determinants of Congenital Heart Defect Risk. Principal Investigator: Charlotte Hobbs, MD, PhD. National Institute for Child Health and Human Development.
Co-Investigator: Cooperative Agreement to Establish Centers of Excellence to Provide Surveillance Research Services and Evaluation Aimed at Prevention of Birth Defects. Principal Investigator: Charlotte Hobbs, MD, PhD. Centers for Disease Control and Prevention.
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