Stewart L. MacLeod, PhD
Assistant Professor, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences Managing and Technical Director, Genomics Core Lab at the Winthrop P. Rockefeller Cancer Institute (WPRIC) Technical Director, Genomics laboratory in the Center for Birth Defects Research and Prevention
Phone: (501) 364-4616

Dr. MacLeod is the technical director of the Genomics laboratory in the Center for Birth Defects Research and Prevention at the Arkansas Children’s Hospital Research Institute and . The focus of the research conducted by the lab is to determine the underlying genetic factors that contribute to the risk of structural birth defects, with special interest in genetic polymorphisms in genes involved in folate metabolism. In addition, we have also undertaken an investigation into the role of differential DNA methylation as a contributor to birth defects risk. 

MacLeod SL, Sinha R, Kadlubar FF, Lang NP.  Polymorphisms of CYP1A1 and GSTM1 influence the in vivo function of CYP1A2.  Mutation Research. 376:135-142, 1997.

MacLeod, S. L., Nowell, S., Plaxco, J., Lang, N.P. An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer, Annals of Surgical Oncology. 7: 777-782, 2000.

MacLeod SL. Nowell S. Massengill J. Jazieh A. McClure G. Plaxco J. Kadlubar FF. Lang NP.  Cancer therapy and polymorphisms of cytochromes P450. Clinical Chemistry & Laboratory Medicine. 38(9): 883-887, 2000.

Pashov A. Canziani G. Macleod S. Plaxco J. Monzavi-Karbassi B. Kieber-Emmons T. Targeting carbohydrate antigens in HIV vaccine development.  Vaccine. 23(17-18):2168-75, 2005.

Ross CC. MacLeod SL. Plaxco JR. Froude JW. Fink LM. Wang J. Stites WE. Hauer-Jensen M. Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium. Radiation Research. 169(4):408-16, 2008 Apr.

Hakkak R, Shaaf S, Jo C-H, MacLeod S, Korourian S. Dehydroepiandrosterone intake protects against 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in the obese Zucker rat model . Oncology Reports 2010 24:357-362.

Hobbs CA, Cleves MA, Karim MA, Zhao W, MacLeod SL. Maternal Folate-Related Gene Environment Interactions and Congenital Heart Defects. Obstetrics & Gynecology 2010 116(2 Pt 1):316-322.

Cleves MA, Hobbs CA, Zhao W, Krakowiak PA, MacLeod SL. National Birth Defects Prevention Study. Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysis. Paediatric and Perinatal Epidemiology 2011 March; 25:124-134.

Chowdhury S, Hobbs CA, MacLeod SL, Cleves MA, Melnyk S, James SJ, Hu P, Erickson SW. Associations between maternal genotypes and metabolites implicated in congenital heart defects. Mol Genet Metab. 2012 Nov;107(3):596-604. doi: 10.1016/j.ymgme.2012.09.022. Epub 2012 Sep 27.

*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.

Research Support

Co-Investigator: Genetic and Metabolic Determinants of Congenital Heart Defect Risk. Principal Investigator: Charlotte Hobbs, MD, PhD. National Institute for Child Health and Human Development.

Co-Investigator: Cooperative Agreement to Establish Centers of Excellence to Provide Surveillance Research Services and Evaluation Aimed at Prevention of Birth Defects. Principal Investigator: Charlotte Hobbs, MD, PhD. Centers for Disease Control and Prevention.