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Charles K Lumpkin, Jr, MA, PhD
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Professor of Pediatrics, Department of Pediatrics, University of Arkansas for Medical Sciences/College of Medicine |
Phone: (501) 364-1100 |
Research Overview
Dr. Lumpkin is a member of ACHRI's Pediatric Endocrinology and Diabetes Research Working Group, a collaborative effort among ACHRI and UAMS investigators who share a common interest in the study of Types I and II diabetes in children and adolescents. The group's objectives center on the development of strategies for prevention, treatment, and improved management of these diseases. Bone disease is now a recognized complication of diabetes, and Dr. Lumpkin has been instrumental in working with Dr. Kathryn Thrailkill, MD, and Dr. John Fowlkes, MD, to develop new techniques to study bone disease in diabetes. Using distraction osteogenesis, a method perfected by Dr. James Aronson, MD, Dr. Lumpkin and the diabetes team have begun to examine how insulin deficiency (Type I diabetes) and insulin resistance (Type II diabetes) impact on new bone formation. Currently, he is exploring treatments that may improve bone formation in both types of diabetes.
Dr. Lumpkin’s laboratory also investigates the effects of alcohol on bone formation. Epidemiological data suggest that skeletal pathology caused by excessive alcohol consumption may cost the US economy $2 billion annually. Patients with alcoholic bone disease display marked impairment in bone formation. The long-term goals of his research are to determine the biological mechanisms underlying this process and to explore therapeutic solutions.
Key Publications
Smith JR, Lumpkin CK Jr., Jones RB. A stochastic model for cellular senescence. Part 1: Theoretical considerations. J Theor Biol 86:581, 1981.
Lumpkin CK Jr., McClung JK, Pereira-Smith OM, Smith JR. Antiproliferative mRNAs isolated from senescent and quiescent human fibroblasts. Science 232:393, 1986.
Aronson J, Liu L, Liu Z, Gao GG, Perrien D, Brown E, Skinner RA, Thomas JR, Morris KD, Suva LJ, Badger TM, Lumpkin CK Jr. Decreased endosteal membranous bone formation accompanies aging in a mouse model of distraction osteogenesis. e-biomed,J Regenerative Med 3:7-15, 2002.
Thrailkill KM, Liu L, Wahl EC, Bunn RC, Cockrell GE, Perrien DS, Skinner RA, Fowlkes JF, Aronson J, Lumpkin CK Jr. Bone formation is impaired in a model of type 1 diabetes. Diabetes 54:2875-2881, 2005.
Shankar K, Hidestrand M, Haley R, Skinner RA, Hogue W, Jo CH, Simpson P, Lumpkin CK Jr, Aronson J, Badger TM, Ronis MJ. Different molecular mechanisms underlie ethanol-induced bone loss in cycling and pregnant rats. Endocrinology 147:166-178, 2006.
*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.
Research Support
NIH: Ethanol and Osteoblastogenesis: Roles of IL-1 and TNF