Insook Kim, PhD |
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| Research Associate Professor, Department of Pediatrics, University of Arkansas for Medical Sciences |
| Phone: (501) 364-4592 |
Research Overview
Dr. Kim is a research associate professor in Department of Pediatrics. Her ongoing research interests include: (1) understanding the mechanism of developing carotid body (CB) maturation, (2) blood oxygen sensing mechanism, and (3) the effects of altered oxygen exposures (chronic hypoxia, chronic hyperoxia, and chronic intermittent hypoxia) on CB chemoreceptor function. Dr. Kim was recently funded with two NIH R01s to study the mechanism of developing CB oxygen sensing maturation and the mechanism of perinatal-hyperoxic suppression of chemoreceptor function. Dr. Kim has also investigated the effects of chronic intermittent hypoxia, which mimics obstructive sleep apnea (OSA), on the maturation of CB chemoreceptor function (funded by ACHRI/CUMG). The ultimate clinical impact of work is to find the way to treat or prevent number of potentially life threatening disorders such as asthma, bronchopulmonary dysphasia, sudden infant death syndrome (SIDS), and obstructive sleep apnea (OSA).
Key Publications
Insook Kim, Dongjin Yang, Xinyu Tang and John L. Carroll (2011) Reference gene validation for qPCR in rat carotid body during postnatal development, BMC Research Notes, 4(1):440
Ryan W. Bavis, Insook Kim, Nelish Pradhan, Nawshaba Nawreen, Elizabeth F. Dmitrieff, John L. Carroll, David F. Donnelly (2011) Recovery of carotid body O2 sensitivity following chronic postnatal hyperoxia in rats, Respiratory Physiology & Neurobiology, 177:47-55
Donghee Kim, Justin R. Papreck, Insook Kim, David F. Donnelly, John L. Carroll (2011) Oxygen sensitivity of TASK in carotid body glomus cells during early postnatal development, Respiratory Physiology & Neurobiology Respiratory Physiology & Neurobiology, 177:228-35
David F Donnelly, Insook Kim, Dongjin Yang, John L Carroll (2011) Role of MaxiK-type calcium dependent K+ channels in rat carotid body hypoxia transduction during postnatal development, Respiratory Physiology & Neurobiology, 177:1-8
Donghee Kim, Insook Kim, Justin Papreck, David F. Donnelly, John L. Carroll (2011) Chracterisation of an ATP-sensitive K+ channel in rat carotid body glomus cells, Respiratory Physiology & Neurobiology Respiratory Physiology & Neurobiology, 177:247-55
David F. Donnelly, Ryan W. Bavis, Insook Kim, John L. Carroll (2009) Time-course of alterations in pre- and post-synaptic chemoreceptor function during developmental hyperoxia, Respiratory Physiology & Neurobiology, 168:189-97
Donghee Kim, Eric J. Cavanaugh, Insook Kim, John L. Carroll (2009) Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+ channel in rat carotid body glomus cells, J. Physiology, April 29, 2009, 587(12):2963-75
Insook Kim, Yang DJ, Donnelly DF, and Carroll JL (2009) Fluoresceinated Peanut agglutinin (PNA) is a marker for live O2 sensing glomus cells in rat carotid body, Advances in Experimental Medicine and Biology (Adv Exp Med Biol), 648:185-190
Carroll JL, Insook Kim, Dbouk H, Yang DJ, Bavis RW and Donnelly DF (2009) Time-dependence of hyperoxia-induced impairment in peripheral chemoreceptor activity and glomus cell calcium response, Adv Exp Med Biol. 648:299-306
Kim JH, Insook Kim, and Carroll JL (2009) Modification of relative gene expression ratio measured by real time PCR using mathematical equations, Adv Exp Med Biol. 648:125-135
Research Support
NIH, R01 (as Co-I), “Postnatal resetting of chemoreceptor sensitivity”, Jan 2008- Dec 2011, $1,528,639
NIH, R01 (as Co-I) “Mechanism of perinatal-hyperoxic suppression of chemoreceptor function”, Jul 2007 – Jun 2012, $862,500
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