Jeffrey R. Kaiser, MD, MA
Associate Professor of Pediatrics and Obstetrics and Gynecology at the University of Arkansas for Medical Sciences /College of Medicine/Department of Pediatrics
Phone: (501) 364-1000

Jeffrey R. Kaiser, MD, MA, is an Associate Professor of Pediatrics and Obstetrics and Gynecology at the University of Arkansas for Medical Sciences. He is a neonatologist at Arkansas Children’s Hospital and the University of Arkansas for Medical Sciences. Dr. Kaiser’s research is focused on brain injury in premature and term infants. He studies the development of cerebral autoregulation in premature infants. He has demonstrated that a majority of premature infants possess intact cerebral autoregulation as early as 6 hours of life. Dr. Kaiser and his collaborators were the first in the world to show that increasing carbon dioxide levels are associated with increasingly impaired cerebral autoregulation in premature infants. They also observed that elevated carbon dioxide levels are associated with the development of severe intraventricular hemorrhage in premature infants.

Dr. Kaiser was also the Arkansas Children’s Hospital site principal investigator for the Selective Head Cooling for the Treatment of Perinatal Hypoxic-Ischemic Encephalopathy study. Full-term infants subjected to hypoxic-ischemic injury were cooled with a head cooling cap for 72 hours. Dr. Kaiser and the UAMS neonatologists have cooled over 50 infants and cooled the first in the world with the new FDA-approved cooling equipment.

Kaiser JR, Gauss CH, Williams DK. Surfactant administration acutely affects cerebral and systemic hemodynamics and gas exchange in very low birth weight infants. J Pediatr 2004; 144: 809-814.

Kaiser JR, Gauss CH, Williams DK. The Effects of hypercapnia on cerebral autoregulation in ventilated very low birth weight infants. Pediatr Res 58 (5):931-935, 2005.

Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, Polin RA, Robertson CM, Thoresen M, Whitelaw A, Gunn AJ, on behalf of the CoolCap Study Group. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicenter randomised trial. The Lancet, 2005; 365: 663-670.

Kaiser JR, Gauss CH, Pont MK, Williams DK. Hypercapnia during the first three days of life is associated with severe intraventricular hemorrhage in very low birth weight infants. J Perinatol, 2006; 26:279-285.

Kaiser JR, Gauss CH, Williams DK. Tracheal suctioning is associated with prolonged disturbances of cerebral hemodynamics in very low birth weight infants. J Perinatol, 2008; 28: 34-41.

Tuzcu V, Nas S, Ulusar U, Ugur A, Kaiser JR. Altered fractal heart rate dynamics as a predictor of intraventricular hemorrhage in very low birth weight neonates. Pediatrics, Accepted with revisions.

NIH/NINDS Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage, Principal Investigator.

NIH/NINDS Gene Targets for Intraventricular Hemorrhage, Site Investigator.

Arkansas Children’s Hospital Site Principal Investigator, Brain-Cooling for the Treatment of Perinatal Hypoxic-Ischemic Encephalopathy, Olympic Medical.