| Laura James, MD |
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| Professor of Pediatrics, University of Arkansas for Medical Sciences/College of Medicine/Department of Pediatrics |
| Adjunct Appointment, University of Arkansas for Medical Sciences/Department of Pharmacology and Toxicology |
| Phone: (501) 364-1418 |
Research Overview
Dr. Laura James’ research focus is on acetaminophen toxicity and addresses the study of mechanisms of toxicity and biomarkers of toxicity in animal models and clinical samples. The role of the liver’s endogenous response to acetaminophen-mediated liver injury is a major interest in the laboratory’s work in the mouse model. In addition, using “omic” approaches to understand the potential role of acetaminophen in disease expression or disease susceptibility is a focus. Dr. James also oversees clinical trials in children that are addressing the appropriate and safe use of a number of medications in children.
Key Publications
Donahower B, McCullough SS, Kurten R, Lamps LW, Simpson P, Hinson JA, James LP. Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity. American Journal of Physiology: Liver and Gastrointestinal Physiology 2006;291:G102-G209.
James LP, Donahower B, Burke AS, Mccullough S, Hinson JA. Induction of the nuclear factor HIF-1a in livers of acetaminophen treated mice and freshly isolated hepatocytes: evidence for oxidative stress. Biochem and Biophys Res Comm 2006;343:171-176.
Donahower BC, McCullough SS, Simpson PM, Lamps L, Stowe CD, Kurten R, Hinson JA, James LP. Examination of exogenous hrVEGF in a mouse model of acetaminophen toxicity. JPET 2010; 334(1):33-43.
Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP. Acetaminophen hepatotoxicity and HIF-1a induction in mice occurs without hypoxia. Toxicol Appl Pharmacol 2011;252(3):211-20.
Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP. Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia. Toxicol Appl Pharmacol 2011;252:211-220.
Khandelwal N, James LP, Sanders C, Larson AM, Lee WM, and the Acute Liver Failure Study Group. Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. Hepatology 2011;53(2):567-76.
Brown AT, Ou X, James LP, Jambhekar K, Pandey T, McCullough S, Chaudhuri S, Borrelli MJ. Correlation of MRI findings to histology of acetaminophen toxicity in the mouse. Magn Reson Imaging 2011;30(2):283-9.
Gokhale M, Cleves M, Foster H, Hogan W, James LP, Martin B. Prescription acquired acute and chronic acetaminophen use and renal toxicity: a case control study. J Manag Care Pharm 2012; 18(3):234-46.
*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.
Research Support
STTR/2R42DK079387; NIH/NIDDK; Adduct Dipstick for Diagnosis of Acetaminophen Toxicity
1R01 DK081406; NIH/NIDDK; Identification of new mechanistic biomarkers of adverse responses to acetaminophen in children and adolescents.
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