Laura James, MD
Professor of Pediatrics, University of Arkansas for Medical Sciences/College of Medicine/Department of Pediatrics
Adjunct Appointment, University of Arkansas for Medical Sciences/Department of Pharmacology and Toxicology
Phone: (501) 364-1418

Dr. Laura James’ research focus is on mechanisms and pathways of recovery in the liver following acetaminophen toxicity in the mouse. In September 2007, the National Institute of Diabetes and Digestive Disease (NIDD) awarded her an R01 grant to examine the role of hypoxia inducible factor 1 alpha and VEGF in repair processes in the mouse liver after toxic dosing of acetaminophen. Dr. James is also interested in the development of assays for measuring biomarkers of acetaminophen toxicity in clinical samples from patients with acute acetaminophen overdose and liver failure and in patients receiving therapeutic exposures to acetaminophen. She currently serves as the Principal Investigator for the Arkansas Children’s Hospital PPRU. The PPRU is one of 13 centers nationally participating in the Network of Pediatric Pharmacology Research Units funded by the National Institute of Child Health and Human Diseases.

Donahower B, McCullough SS, Kurten R, Lamps LW, Simpson P, Hinson JA, James LP. Vascular Endothelial Growth Factor and Hepatocyte Regeneration in Acetaminophen Toxicity. American Journal of Physiology: Liver and Gastrointestinal Physiology. 2006;291:G102-G209.

James LP, Donahower B, Burke AS, Mccullough S, Hinson JA. Induction of the nuclear factor HIF-1a in livers of acetaminophen treated mice and freshly isolated hepatocytes: evidence for oxidative stress. Biochemical and Biophysical Research Communications 2006;343:171-176.

Blake MJ, Gaedigk A, Pearce RE, Bomgaars LR, Christensen ML, Stowe C, James LP, Wilson JT, Kearns GL, Leeder JS. Ontogeny of Dextromethorphan O- and N-demethylation in the First Year of Life. Clinical Pharmacology & Therapeutics 2007; 81(4): 510-6.

Vaquero J, Belanger M, James LP, Herrero R, Desjardins P, Cote J, Blei AT, Butterworth RF. Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology 2007;132(1): 372-83.

James LP, Walson P, Lomax K, Kao R, Varughese S, Reyes J. Pharmacokinetics and Tolerability of Rabeprazole in Patients Ages 12 to 16 years with gastroesophageal reflux disease. Clinical Therapeutics, In Press September 2007.

Donahower B, McCullough S, Hennings L, Simpson PM, Stowe CD, Saad AG, Kurten RC, Hinson JA, James LP. Human recombinant Vascular Endothelial Growth Factor (hrVEGF) Reduces Necrosis and Enhances Hepatocyte Regeneration in a Mouse Model of Acetaminophen Toxicity. J Pharmacol Exp Ther. 2010 Apr 2. [Epub ahead of print]

Seely KA, Prather PL, James LP, Moran JH. Marijuana-based drugs: Innovative therapeutics or designer drugs of abuse?. Molecular Interventions 2011 Feb; 11(1):36-51.

Hubbard JJ, James LP. Complications and outcomes of brown recluse spider bites in children. Clin Pediatr (Phila). 2011 Mar;50(3):252-8. Getachew Y, James LP, Lee WM, Thiele DL, Miller BC. Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. Biochem Pharm 2010 May; 79(9):1363-71.

Heard K, Green J, James LP, Judge B, Rhyee S, Zolot L, Dart R. Acetaminophen-cystiene adducts during therapeutic dosing and following overdose. BMC Gastroenterology 2011 Mar; 14:11-20.

Farst K, Reading-Meyer JA, Bird TM, Worthington T, James LP, Robbins JM. Hair drug testing of children suspected of exposure to the manufacture of methamphetamine. J of Forensic and Legal Medicine 2011 Apr; 18(3):110-4.

Lash L, Agerwal R, Macmillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, Hinson JA. Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase. JPET 2011 Apr; 337(1):110-8.

Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP. Acetaminophen hepatotoxicity and HIF-1alpha induction in mice occurs without hypoxia. Toxicol Appl Pharmacol 2011 May; 252(3):211-220.

Milesi-Halle A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP. Indocyanin green clearance varies as a function of n-acetylcysteine treatment in a murine model of acetaminophen toxicity chemico-biological interactions. Chemico Biol Interact 2011 189(222-229).

Ceelie I, James LP, Gijsen V, Mathot RAA, Ito S, Tesselaar C, Tibboel D, Koren G, de Wildt SN. Acute liver failure after recommended doses of acetaminophen in patients with myopathies. Crit Care Med 2011 39(4):1-6.

*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.

NIH/NIDDK: Evaluation of a biomarker for acetaminophen toxicity
NIH: Multicenter Study of Acute Liver Failure in Children