| Laura James, MD |
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| Professor of Pediatrics, University of Arkansas for Medical Sciences/College of Medicine/Department of Pediatrics |
| Adjunct Appointment, University of Arkansas for Medical Sciences/Department of Pharmacology and Toxicology |
| Phone: (501) 364-1418 |
Research Overview
Dr. Laura James’ research focus is on mechanisms and pathways of recovery in the liver following acetaminophen toxicity in the mouse. In September 2007, the National Institute of Diabetes and Digestive Disease (NIDD) awarded her an R01 grant to examine the role of hypoxia inducible factor 1 alpha and VEGF in repair processes in the mouse liver after toxic dosing of acetaminophen. Dr. James is also interested in the development of assays for measuring biomarkers of acetaminophen toxicity in clinical samples from patients with acute acetaminophen overdose and liver failure and in patients receiving therapeutic exposures to acetaminophen. She currently serves as the Principal Investigator for the Arkansas Children’s Hospital PPRU. The PPRU is one of 13 centers nationally participating in the Network of Pediatric Pharmacology Research Units funded by the National Institute of Child Health and Human Diseases.
Key Publications
Donahower B, McCullough SS, Kurten R, Lamps LW, Simpson P, Hinson JA, James LP. Vascular Endothelial Growth Factor and Hepatocyte Regeneration in Acetaminophen Toxicity. American Journal of Physiology: Liver and Gastrointestinal Physiology. 2006;291:G102-G209.
James LP, Donahower B, Burke AS, Mccullough S, Hinson JA. Induction of the nuclear factor HIF-1a in livers of acetaminophen treated mice and freshly isolated hepatocytes: evidence for oxidative stress. Biochemical and Biophysical Research Communications 2006;343:171-176.
Blake MJ, Gaedigk A, Pearce RE, Bomgaars LR, Christensen ML, Stowe C, James LP, Wilson JT, Kearns GL, Leeder JS. Ontogeny of Dextromethorphan O- and N-demethylation in the First Year of Life. Clinical Pharmacology & Therapeutics 2007; 81(4): 510-6.
Vaquero J, Belanger M, James LP, Herrero R, Desjardins P, Cote J, Blei AT, Butterworth RF. Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology 2007;132(1): 372-83.
James LP, Walson P, Lomax K, Kao R, Varughese S, Reyes J. Pharmacokinetics and Tolerability of Rabeprazole in Patients Ages 12 to 16 years with gastroesophageal reflux disease. Clinical Therapeutics, In Press September 2007.
*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.
Research Support
NIH/NIDDK: Evaluation of a biomarker for acetaminophen toxicity
NIH: Multicenter Study of Acute Liver Failure in Children
NIH/NICHD: Pediatric Pharmacology Research Unit Network
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