John Fowkles

John Fowlkes, MD

Professor of Endocrinology, University of Arkansas for Medical Sciences,College of Medicine, Department of Pediatrics

Division Chief, Pediatric Endocrinology, Arkansas Children's Hospital

Phone: (501) 364-1100

Research Overview

John Fowlkes, M.D., is a professor within the University of Arkansas for Medical Sciences (UAMS) College of Medicine's (COM) Department of Pediatrics and the division chief of Pediatric Endocrinology at Arkansas Children's Hospital. Dr. Fowlkes is a member of ACHRI's Diabetes Research Working Group, a collaborative effort among ACHRI and UAMS investigators who share a common interest in the study of Types I and II diabetes in children and adolescents. The group's objectives center on the development of strategies for prevention, treatment, and improved management of these diseases.

Dr. Fowlkes’ primary research focuses on the effects of insulin-like growth factors on bone formation. He, in collaboration with other members of the working group, is investigating the physiology of insulin-like growth factor binding proteins in bone and the effects of growth hormone on bone formation. A greater understanding of the relationship of these proteins and bone metabolism will allow development of therapeutic interventions to enhance bone formation in individuals with a variety of bone disorders such as osteoporosis and metabolic bone diseases. The National Institutes of Health recently renewed this grant to continue studies on the effects of insulin-like growth factors on bone health.

Key Publications

Thrailkill, K.M., Lumpkin, C.K., Jr., Bunn, R.C., Kemp, S.F., and Fowlkes, J.L.: Is insulin an anabolic agent in bone: Dissecting the diabetic bone for clues. American Journal of Physiology - Endocrinology & Metabolism 289:E735-745, 2005.

Thrailkill, K.M., Liu, L., Wahl, E.C., Bunn, R.C., Perrien, D.S., Cockrell, G.E., Skinner, R.A., Hogue, W.R., Carver, A., Fowlkes, J.L., Aronson, J., and Lumpkin, C.K., Jr.: New bone formation is impaired in a model of Type I Diabetes Mellitus. Diabetes 54:2875-2881, 2005.

Thrailkill, K.M., Moreau, C.S., Cockrell, G.E., Simpson, P., Goel, R., North, P., Fowlkes, J.L., Bunn, R.C.: Physiological Matrix Metalloproteinase concentrations in serum during childhood and adolescence, using Luminex Multiplex Technology, Clinical Chemistry and Laboratory Medicine 43:1392-1399, 2005.

Fowlkes, J.L., Thrailkill, K.M., Liu, L., Wahl, E.C., Bunn, R.C., Cockrell, G.E., Perrien, D.S., Skinner, R.A., Coleman, H., Aronson, J., Lumpkin, C.K. Jr.: Effects of local and systemic administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model. Journal of Bone and Mineral Research, 21(9): 1359-1366, 2006.

Liu, Z., Aronson, J., Wahl, E.C., Liu, L., Perrien, D.S., Kern, P.A., Fowlkes, J.L., Thrailkill, K.M., Bunn, R.C., Cockrell, G.E., Skinner, R.A., Lumpkin, C.K., Jr.: A novel rat model for the study of deficits in bone formation in type 2 diabetes. Acta Orthopaedica, 78(1): 46-55, 2007.

Thrailkill K.M., Bunn R.C., Moreau C.S., Cockrell G.E., Simpson P.M., Coleman H.N., Frindik J.P., Kemp S.F., Fowlkes J.L.. MMP-2 dysregulation in Type 1 Diabetes Mellitus. Diabetes Care. 2007 Jun 11; [Epub ahead of print]

Fowlkes J.L., Bunn R.C., Coleman H.N., Hall B., Reid M.C., Thrailkill K.M. Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type). Growth Horm IGF Res. 2007 Jun 6; [Epub ahead of print]

*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.

Research Support

National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases: The Physiology of IGFBP-degrading Proteinases in Bone