| Nicolaas E.P. Deutz, MD, PhD
|
Professor of Geriatrics, Pediatrics, and Nutrition, University of Arkansas for Medical Sciences, College of Medicine |
Phone: (501) 352-6626 |
Research Overview
Joining UAMS in 2006, Dr. Deutz has over 20 years experience in clinical nutrition and metabolism research in animals and humans and has published over 200 papers in this research field. He studied medicine at the University of Amsterdam and obtained his M.D. in 1983. After a short period as a Clinical Fellow at the Department of Neurosurgery in Amsterdam, he initiated his basic neurochemical research at the University of Amsterdam and Delft University of Technology, both in the Netherlands, earning his Ph.D. in 1988 with his thesis on hepatic encephalopathy. He next joined the Clinical Nutrition and Metabolism Group of the Department of Surgery of Maastricht University, also in The Netherlands. Since then, he has focused his research on (inter)organ protein and amino acid metabolism using animals (mice, rats, pigs), healthy humans, and patients with various acute and chronic diseases, including (pre)diabetes, cancer, COPD, sepsis, liver and gut failure. Throughout his scientific career, he has continuously supervised Ph.D. students and is a co-organizer of a number of international post-graduate courses. He became a member of the Scientific Committee of the European Society of Parenteral and Enteral Nutrition (ESPEN) in 1988, and from 2000 to 2005 he chaired this committee. Since 2006, he has served as Editor-in-Chief of the Society’s journals: Clinical Nutrition, Clinical Nutrition Supplements, and e-SPEN.
Key Publications
Engelen MP, Rutten EP, De Castro CL, Wouters EF, Schols AM, Deutz NE. Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2007;85:431-9.
Rutten EP, Franssen FM, Engelen MP, Wouters EF, Deutz NE, Schols AM. Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2006;83:829-34.
Kreymann KG, Berger MM, Deutz NE, et al. ESPEN Guidelines on Enteral Nutrition: Intensive care. Clin Nutr 2006;25:210-23.
Vissers YL, Dejong CH, Luiking YC, Fearon KC, von Meyenfeldt MF, Deutz NE. Plasma arginine concentrations are reduced in cancer patients: evidence for arginine deficiency? Am J Clin Nutr 2005;81:1142-6.
Engelen MP, Rutten EP, De Castro CL, Wouters EF, Schols AM, Deutz NE. Altered interorgan response to feeding in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2005;82:366-72.
Luiking YC, Poeze M, Dejong CH, Ramsay G, Deutz NE. Sepsis: an arginine deficiency state? Crit Care Med 2004;32:2135-45.
Jalan R, Olde Damink SW, Deutz NE, Hayes PC, Lee A. Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension. Gastroenterology 2004;127:1338-46.
Hallemeesch MM, Janssen BJA, De Jonge WJ, Soeters PB, Lamers WH, Deutz NEP. NO production by cNOS and iNOS reflects blood pressure changes in LPS-challenged mice. Am J Physiol Endocrinol Metab 2003;285:E871-875.
Bruins MJ, Soeters PB, Lamers WH, Deutz NE. L-arginine supplementation in pigs decreases liver protein turnover and increases hindquarter protein turnover both during and after endotoxemia. Am J Clin Nutr 2002;75:1031-44.
Research Support
Unilever-Nutreco. GUARD: Nutrition of the Gut. Feed/Food solutions for the infected gut. 2007-2009
ESPEN NESTLE research fellowship: “The effect of cancer and surgery on the inter-organ protein response to feeding”. 2007-2008
Absorption kinetics of peptides in pigs. Unilever/DSM. 2004-2007
TIFN: Microbe mediated gut metabolism in the pig. 2007-2008
TIFN: Microbe mediated gut metabolism in the mouse. 2007-2008
Unilever: Absolute Bioavailability of Hoodia Scrodial Glycosides in pigs #06D7X. 2007-2008
Novartis Medical Nutrition: Study in septic-shock ICU patients in which Arginine was infused to improve their condition. 2007-2008