R Clay Bunn, PhD
Research Assistant Professor , University of Arkansas for Medical Sciences/College of Medicine/Department of Pediatrics
Phone: (501) 364- 4589

Dr. Bunn is an instructor within the UAMS Department of Pediatrics and is a member of the Arkansas Children’s Hospital Research Institute’s Diabetes Research Working Group. Dr. Bunn was recently funded for three years by the American Diabetes Association to study the impact that insulin may have on macrophage behavior and how this may be linked to the diabetic complication of atherosclerosis. Dr. Bunn’s other research interests include regulation of growth factor bioavailability and regulators of adipogenesis.

Wahl EC, Aronson J, Liu L, Skinner RA, Miller MJ, Cockrell GE, Fowlkes JL, Thrailkill KM, Bunn RC, Ronis MJ, Lumpkin CK Jr. Direct bone formation during distraction osteogenesis does not require TNFalpha receptors and elevated serum TNFalpha fails to inhibit bone formation in TNFR1 deficient mice. Bone 2010 February; 46(2):410-417.

Wahl EC, Aronson J, Liu L, Fowlkes JL, Thrailkill KM, Bunn RC, Skinner RA, Miller MJ, Cockrell GE, Clark LM, Ou Y, Isales CM, Badger TM, Ronis MJ, Sims J, Lumpkin CK Jr. Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J Bone Miner Res 2010 January; 25(1):114-123.

Kathryn M. Thrailkill, Cynthia S. Moreau, Gael E. Cockrell, Chan-Hee Jo, Robert C. Bunn, Alba E. Morales-Pozzo, Charles K. Lumpkin, John L. Fowlkes. Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus. Endocrine. January 2010. [Epub ahead of print]

Fowlkes JL, Bunn RC, Liu L, Wahl EC, Coleman HN, Cockrell GE, Perrien DS, Lumpkin CK Jr, Thrailkill KM. Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are downregulated throughout osteogenesis in type 1 diabetes mellitus. Endocrinology 149(4):1697-1704, 2008. 22.

Thrailkill KM, Clay Bunn R, Fowlkes JL. Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy. Endocrine. 2009 Feb;35(1):1-10. Epub 2008 Oct 30. 

Thrailkill K.M., Bunn R.C., Moreau C.S., Cockrell G.E., Simpson P.M., Coleman H.N., Frindik J.P., Kemp S.F., Fowlkes J.L.. MMP-2 dysregulation in Type 1 Diabetes Mellitus. Diabetes Care. 2007 Jun 11; [Epub ahead of print]

Fowlkes J.L., Bunn R.C., Coleman H.N., Hall B., Reid M.C., Thrailkill K.M. Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type). Growth Horm IGF Res. 2007 Jun 6; [Epub ahead of print]

Fowlkes JL, Thrailkill KM, Liu L, Wahl EC, Bunn RC, Cockrell GE, Perrien DS, Aronson J, Lumpkin CK Jr. Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model. J Bone Miner Res. 2006 Sep;21(9):1359-66.

Thrailkill K, Cockrell G, Simpson P, Moreau C, Fowlkes J, Bunn RC. Physiological matrix metalloproteinase (MMP) concentrations: comparison of serum and plasma specimens. Clin Chem Lab Med. 2006;44(4):503-4.

Thrailkill KM, Moreau CS, Cockrell G, Simpson P, Goel R, North P, Fowlkes JL, Bunn RC. Physiological matrix metalloproteinase concentrations in serum during childhood and adolescence, using Luminex Multiplex technology. Clin Chem Lab Med. 2005;43(12):1392-9.

Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL. Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E735-45.

Thrailkill KM, Liu L, Wahl EC, Bunn RC, Perrien DS, Cockrell GE, Skinner RA, Hogue WR, Carver AA, Fowlkes JL, Aronson J, Lumpkin CK Jr. Bone formation is impaired in a model of type 1 diabetes. Diabetes. 2005 Oct;54(10):2875-81.

*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.

Lyon Award Regulation of EFGR Ligand Production by Insulin in Macrophages and Adipocytes