| R Clay Bunn, PhD
|
Research Assistant Professor , University of Arkansas for Medical Sciences/College of Medicine/Department of Pediatrics |
Phone: (501) 364-
4589
|
Research Overview
Dr. Bunn is an instructor within the UAMS Department of Pediatrics and is a member of the Arkansas Children’s Hospital Research Institute’s Diabetes Research Working Group. Dr. Bunn was recently funded for three years by the American Diabetes Association to study the impact that insulin may have on macrophage behavior and how this may be linked to the diabetic complication of atherosclerosis. Dr. Bunn’s other research interests include regulation of growth factor bioavailability and regulators of adipogenesis.
Key Publications
Thrailkill K.M., Bunn R.C., Moreau C.S., Cockrell G.E., Simpson P.M., Coleman H.N., Frindik J.P., Kemp S.F., Fowlkes J.L.. MMP-2 dysregulation in Type 1 Diabetes Mellitus. Diabetes Care. 2007 Jun 11; [Epub ahead of print]
Fowlkes J.L., Bunn R.C., Coleman H.N., Hall B., Reid M.C., Thrailkill K.M. Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type). Growth Horm IGF Res. 2007 Jun 6; [Epub ahead of print]
Fowlkes JL, Thrailkill KM, Liu L, Wahl EC, Bunn RC, Cockrell GE, Perrien DS, Aronson J, Lumpkin CK Jr. Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model. J Bone Miner Res. 2006 Sep;21(9):1359-66.
Thrailkill K, Cockrell G, Simpson P, Moreau C, Fowlkes J, Bunn RC. Physiological matrix metalloproteinase (MMP) concentrations: comparison of serum and plasma specimens. Clin Chem Lab Med. 2006;44(4):503-4.
Thrailkill KM, Moreau CS, Cockrell G, Simpson P, Goel R, North P, Fowlkes JL, Bunn RC. Physiological matrix metalloproteinase concentrations in serum during childhood and adolescence, using Luminex Multiplex technology. Clin Chem Lab Med. 2005;43(12):1392-9.
Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL. Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E735-45.
Thrailkill KM, Liu L, Wahl EC, Bunn RC, Perrien DS, Cockrell GE, Skinner RA, Hogue WR, Carver AA, Fowlkes JL, Aronson J, Lumpkin CK Jr. Bone formation is impaired in a model of type 1 diabetes. Diabetes. 2005 Oct;54(10):2875-81.
*To find additional publications by this author, please visit Pubmed Central, a National Institutes of Health-operated site for electronic distribution of life sciences research reports.
Research Support
American Diabetes Association – Pro-atherosclerotic gene expression in macrophages
Lyon Award Regulation of EFGR Ligand Production by Insulin in Macrophages and Adipocytes