| Beata D. Przybyla, PhD
|
Research Assistant Professor in the Department of Microbiology and Immunology, University of Arkansas for Medical Sciences |
Phone: (501) 364-
2407
|
Research Overview
Dr. Beata D. Przybyla is a molecular geneticist with a primary research interest in the identification of gene regulatory networks underlying gender bias in autoimmune diseases. She utilizes murine models of autoimmune diseases to identify molecular mechanisms responsible for changes in homeostasis of CD4+ T lymphocytes predisposing to autoimmunity. Specifically, she is interested in molecular pathways regulating interactions of CD+T cells with extracellular matrix. She participates in Dr. Kathleen Gilbert’s project focused on the immunotoxicity of environmental aldehydes. The ultimate goals of Dr. Przybyla’s research include identification of genetic marker panels that would be predictive of the onset of autoimmune diseases. She applies bioinformatics and system biology approaches in her genomic data analyses. She also collaborates with researchers at the FDA’s National Center for Toxicological Research to investigate the alteration of genetic networks by neurotoxins.
Key publications
Dennis RA, Przybyla BD, Gurley C, Kortebein PM, Simpson P, Sullivan, DH, Peterson CA. Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise. Physiol. Genomics (December 11, 2007). doi:10.1152/physiolgenomics.00191.2007
Przybyla BD, Gurley C, Harvey JF, Bearden E, Kortebein P, Evans WJ, Sullivan D, Peterson CA, Dennis RA. Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. Exp. Gerontology, 41:320-7, 2006.
Przybyla-Zawislak BD, Thorn BT, Ali SF, Dennis RA, Virmani V, Amato A, Binienda ZK. (2005) Identification of rat hippocampal mRNAs altered by mitochondrial toxicant: 3-NPA. Ann. N.Y. Acad. Sci. 1053:162-173, 2005.
Przybyla-Zawislak BD, Kim CS, Ali SF, Slikker W Jr., Binienda ZK. The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liver. Neuroscience Letters 381: 354-7, 2005.
Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, Mohrenweiser HW, Maxwell J, Hammock BD, Bradbury, JA, Enayetallah AE, Zeldin DC, Grant DF. Polymorphisms in Human Soluble Epoxide Hydrolase. Molecular Pharmacology 64:482-90, 2003.
McCammon MT, Epstein CB, Przybyla-Zawislak BD, McAlister-Henn L, Butow RA. Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. Molecular Biology of the Cell 14:958-972, 2003.
Support
Children’s University Medical Group