| Sheila Asghar MD, MSc |
|
| Instructor of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences |
| Phone (501) 364-1850 |
Research overview
Dr. Asghar is Director of the Neurobehavioral and Developmental Delay Clinic and serves as a specialist in the Autism Treatment Network Clinic. Her research involves looking at predictive markers of subclinical seizures in children with autism. Along with collaborators Drs. Jill James, Sarah Blossom, and May Griebel, Dr. Asghar is investigating how subclinical seizures affect the redox states, electroencephalogram patterns and adaptive behavior scores of autistic children. An early identification and intervention may prevent progression into overt seizures. Dr. Asghar’s previous research involved the use of amphetamine as a model for mania measuring behavioral and cognitive changes and levels of neurotransmitters such as glutamate and GABA.
Key publications
Asghar SJ, Vedanarayanan V, Fratkin J. “Combo” treatment for mitochondrial myopathies. Is it effective in the long run? Neuropediatrics. Dec 2006 37(S1).
Willson MC, Bell EC, Dave S, Asghar SJ, McGrath BM, Silverstone PH. Valproate attenuates dextroamphetamine-induced subjective changes more than lithium. Eur Neuropsychopharmacol. Dec 2005;15(6):633-639.
Bell EC, Willson MC, Wilman AH, Dave S, Asghar SJ, Silverstone PH. Lithium and valproate attenuate dextroamphetamine-induced changes in brain activation. Hum Psychopharmacol. Mar 2005;20(2):87-96.
Willson MC, Wilman AH, Bell EC, Asghar SJ, Silverstone PH. Dextroamphetamine causes a change in regional brain activity in vivo during cognitive tasks: a functional magnetic resonance imaging study of blood oxygen level-dependent response. Biol Psychiatry. Aug 15 2004;56(4):284-291.
Wu RH, O'Donnell T, Ulrich M, Asghar SJ, Hanstock CC, Silverstone PH. Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate. Ann Gen Hosp Psychiatry. Jul 30 2004;3(1):13.
Silverstone PH, Asghar SJ, O'Donnell T, Ulrich M, Hanstock CC. Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients. World J Biol Psychiatry. Jan 2004;5(1):38-44.
Asghar SJ, Tanay VA, Baker GB, Greenshaw A, Silverstone PH. Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers. Hum Psychopharmacol. Jun 2003;18(4):291-299.
Current research funding
CUMG
|
