May 2013

Dr. Thomas Badger (center) with ACH Board Chairman Tom Baxter (left) and ACHRI President Richard F. Jacobs, MD (right)
Dr. Thomas M. Badger Receives Inaugural Dr. Robert H. Fiser Jr. Research Achievement Award

Thomas M. Badger, PhD, is first recipient of The Dr. Robert H. Fiser, Jr. Research Achievement Award.  The award was presented by Dr. Richard Jacobs at the annual Ruth Olive Beall Service Awards banquet on April 25, 2013. The award was created to honor the accomplishments of an ACHRI research scientist who has distinguished himself or herself through extraordinary scientific research that will have lasting impact on the health, development, and well-being of children and their families.

As a neuroendocrinologist and nutritionist, Dr. Badger has devoted most of his career to understanding the role of nutritional status and dietary factors on endocrine-regulated aspects of development, growth, and metabolism. In 1986, he joined Dr. Robert Fiser’s faculty in the Department of Pediatrics.He was recruited to help Dr. Fiser strengthen the research program within the department by completing two major tasks: 1) develop a private research institute and 2) bring one of the national nutrition research centers to Arkansas.
Dr. Robert Harold Fiser, Jr.
April 7, 1942 - July 20, 2011
ACHRI’s Research Achievement Award is named in honor of the late Dr. Robert H. Fiser, Jr. Dr. Fiser has been described as a true visionary who dedicated his life’s work to the children of Arkansas.  Among his many accomplishments as UAMS Department of Pediatrics Chairman from 1975 to1994, his leadership was instrumental in laying the foundation for the current success of the Arkansas Children’s Hospital Research Institute

In a few short years, he was successful in facilitating the completion of the first task. In 1990 the Arkansas Children’s Hospital Research Center was incorporated as a nonprofit corporation exclusively to support ACH research. He was named the first president and led the institute for the next nine years.
Alongside Dr. Fiser, Senator Dale Bumpers, and many others, such as board member Charlie Whiteside, he worked tirelessly to bring a federally funded National Human Nutrition Research Center to Arkansas. In 1994, his second major task was achieved when ACH was named one of six institutions in the country to be named a national nutrition center. Thus, the Arkansas Children’s Nutrition Center was established, Dr. Badger was appointed its director.

Dr. Badger has devoted most of his career to understanding the role of nutritional status and dietary factors on development, growth, and metabolism. Leading a multidisciplinary team of scientists, he uses a translational research approach, which moves between studies of genes, cells, animals, pregnant women, and their children. 

To date, under his leadership the ACNC has been awarded $122 million. Among many studies currently underway, the Center is conducting the largest, most comprehensive longitudinal study of children from age 3 months through 6 years which aims to reveal effects of early nutrition on child development.

Cool Research Receives Hot Reception
Wound pain care subsequent to burn injuries is one of the most intense, severe types of pain and can add to the trauma and discomfort pediatric patients already experience from the burn itself. Analgesics and anesthetics used during burn treatments are not completely effect in relieving this severe intermittent pain and have untoward side effects. Dr. Debra Jeffs, Director of Academic Nursing Education at ACH, has completed a study testing the effect of virtual reality (VR) distraction on acute pain intensity on adolescents undergoing burn wound treatment
at the Burn Center at ACH.

To provide the VR distraction for the participating adolescents receiving burn wound care, Dr. Jeffs used SnowWorld, a three-dimensional computer-generated, interactive computer program developed specifically for burn patients. As the patients explore SnowWorld using a VR viewer and computer mouse, they chase snowmen and have an occasional snowball fight. Dr. Jeffs examined whether the SnowWorld excursions decreased pain intensity and if it was more effective than other distractions or standard care. The study is one of the few randomized controlled studies to examine the effectiveness of non-pharmacological strategies in ameliorating the burn treatment pain for pediatric patients.

Despite more pre-procedure pain, the VR group reported less pain during wound care than either passive distraction (watching a DVD) or standard care. The VR group was the only group to have a decrease in pain perception from pre-procedure pain reported to procedural pain reported. Adolescents pre-treated with opiate analgesics and female adolescents reported more pain during wound care. Her study extends evidence supporting VR as effective in lessening burn wound care pain to the adolescent population.

Dr. Jeffs presented her results in a podium presentation, “Effect of Virtual Reality on Adolescent Pain During Burn Wound Care,” at the American Burn Association (ABA) Annual Meeting in April. Her presentation was the first abstract accepted for podium presentation at the ABA annual meeting from the Burn Center at ACH. Her presentation was well received, including praise from Dr. Daniel Peterson of the Human Interface Technology Laboratory at the University of Washington. Dr. Peterson and his colleague Dr. Hunter Hoffman pioneered the use of VR for burn wound care and are the creators of SnowWorld. Their VR studies often focus on the treatment of burns received by military personnel. Dr. Peterson praised the rigorousness of Dr. Jeffs’ study and was impressed by her undertaking for the benefit of pediatric patients.

Dr. Jeffs and her research team are currently completing minor revisions to a manuscript to be published in the Journal of Burn Care and Research. This pilot study has also provided preliminary data for a future study testing the effect of tailoring non-pharmacologic interventions including VR during burn wound care. Dr. Jeffs has contacted other burn treatment centers to secure sites for a multisite study she will propose later this year as part of a grant application to the National Institute of Nursing Research at NIH.

Dr. Jeffs’ study received support from the Arkansas Children’s Hospital Research Institute/Arkansas Biosciences Institute competitive grant program and the Burn Center at ACH.

ACHRI Hosts Successful AAALAC Site Visit
Since 2001, ACHRI has been accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC), a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. To maintain AAALAC accreditation, ACHRI undergoes a comprehensive, extensive evaluation of laboratory animal care and use in our biomedical pediatric research program every three years.

AAALAC conducted its most recent site visit to ACHRI on May 9 to review our institutional support, Institutional Animal Care and Use Committee (IACUC), the management of animal research, and the management of animal care and husbandry. In the exit briefing, the site visitors expressed that ACHRI will be recommended for continued full AAALAC accreditation. This recommendation will be confirmed by the AAALAC Council on Accreditation in September at AAALAC’s annual board meeting.

More than 880 companies, universities, hospitals, government agencies and other research institutions in 37 countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. These institutions volunteer to participate in AAALAC's program, in addition to complying with the local, state, and federal laws that regulate animal research.

Congratulations Blake Harrison, director of animal operations, and his team for the hard work and commitment to ensure responsible animal care and use that resulted in another successful site visit.

President's Choice Publications of the Month
The following articles were selected as this month’s feature publications.

  • Andres A, Casey PH, Cleves MA, Badger TM. Body Fat and Bone Mineral Content of Infants Fed Breast Milk, Cow's Milk Formula, or Soy Formula during the First Year of Life. J Pediatr. 2013 Feb 1. pii: S0022-3476(12)01556-9. doi: 10.1016/j.jpeds.2012.12.067. [Epub ahead of print]

  • Lam F, Ransom C, Gossett JM, Kelkhoff A, Seib PM, Schmitz ML, Bryant JC, Frazier EA, Gupta P. Safety and efficacy of dexmedetomidine in children with heart failure. Pediatr Cardiol. 2013 Apr;34(4):835-41. doi: 10.1007/s00246-012-0546-7. Epub 2012 Oct 9.

ACHRI would like to know about your published findings. As your articles are published, please email or mail a copy to Phaedra Yount (mail slot 842). The number of publications by our researchers is reported to the hospital and ACHRI boards, so it is important that we receive an accurate count of the publications your research produces.

New Industry-Sponsored Projects

PI Agency Project Title Project Period Total Funding
Jose Romero NIH CASG402 2/12-9/13 $15,475.00
Jose Romero NIH CASG401 2/12-9/13 $15,475.00
Adolfo Garnica BioMarin Expanded Access Program BMN 110 4/13-3/14 $114,488.40
Kimo Stine Bayer Healthcare Multi-Center Trial to evaluate the PK, Safety, and Efficacy of BAY 94-9027 for the treatment of Hemophilia A 4/13-3/14 $71,331.00
Mark Heulitt Impact Impact Instrument 1/13-12/13 $100,000.00
Tom Collins Actelion Pharma ACHD Queri 4/13-3/14 $12,000.00
Tom Collins Actelion Pharma EX QuERI 4/13-3/14 $27,000.00

Recent Grant Submissions

PI Program Project Title Project Period Total Funding
Gulnur Com Cystic Fibrosis Foundation Dissemination of Genetic Information Related to Cystic Fibrosis 8/31/2013-7/31/2015 $43,200.00
Richard Frye NIH Mitochondrial Dysfunction in Autism Spectrum Disorder 9/1/2013-8/31/2018 $3,677,275.00
Maya Lopez HRSA Early Childhood Comprehensive Systems:  Building Health Through Integration 8/1/2013-7/31/2016 $419,997.00

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